Akt targeting as a strategy to boost chemotherapy efficacy in non-small cell lung cancer through metabolism suppression

Metabolic reprogramming is a hallmark of cancer development, mediated by genetic and epigenetic alterations that may be pharmacologically targeted. Among oncogenes, the kinase Akt is commonly overexpressed in tumors and favors glycolysis, providing a rationale for using Akt inhibitors. Here, we addr...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Le Grand, Marion, Berges, Raphael, Pasquier, Eddy, Montero, Marie-Pierre, Borge, Laurence, Carrier, Alice, Vasseur, Sophie, Bourgarel, Veronique, Buric, Duje, André, Nicolas, Braguer, Diane, Carré, Manon
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362809/
https://ncbi.nlm.nih.gov/pubmed/28332584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45136
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