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DNA Adduct Profiles Predict in Vitro Cell Viability after Treatment with the Experimental Anticancer Prodrug PR104A
[Image: see text] PR104A is an experimental DNA-alkylating hypoxia-activated prodrug that can also be activated in an oxygen-independent manner by the two-electron aldo-keto reductase 1C3. Nitroreduction leads to the formation of cytotoxic hydroxylamine (PR104H) and amine (PR104M) metabolites, which...
Guardat en:
| Publicat a: | Chem Res Toxicol |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical
Society
2017
|
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5362746/ https://ncbi.nlm.nih.gov/pubmed/28140568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.6b00412 |
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