Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice

BACKGROUND: Aging augments endotoxemic cardiac dysfunction, but the mechanism remains unclear. Anti-aging protein Klotho has been found to modulate tissue inflammatory responses. We tested the hypothesis that a reduced Klotho level in aging heart plays a role in the augmented endotoxemic cardiac dys...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Hui, Haipeng, Zhai, Yufeng, Ao, Lihua, Cleveland, Joseph C., Liu, Hongbin, Fullerton, David A., Meng, Xianzhong
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362514/
https://ncbi.nlm.nih.gov/pubmed/28152512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14933
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