Elevated Expression of TLR2 in Aging Hearts Exacerbates Cardiac Inflammatory Response and Adverse Remodeling Following Ischemia and Reperfusion Injury

This study tested the hypothesis that Toll-like receptor 2 (TLR2) augments the inflammatory responses and adverse remodeling in aging hearts to exacerbate myocardial injury and cardiac dysfunction.MethodsOld (20-22 months old) and adult (4-6 months old) mice of C57BL/6 wild-type and TLR2 knockout (K...

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Bibliografiske detaljer
Main Authors: Yufeng Zhai, Lihua Ao, Qingzhou Yao, Erlinda The, David A. Fullerton, Xianzhong Meng
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-04-01
Serier:Frontiers in Immunology
Fag:
aging
TLR2
inflammation
myocardial ischemia
remodeling
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2022.891570/full
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