The tetrahydrobiopterin radical with high- and low-spin heme in neuronal nitric oxide synthase -- a new indicator of the extent of NOS coupling

Reaction intermediates trapped during the single-turnover reaction of the neuronal ferrous nitric oxide synthase oxygenase domain (Fe(II)nNOS(OX)) show four EPR spectra of free radicals. Fully-coupled nNOS(OX) with cofactor (tetrahydrobiopterin, BH(4)) and substrate (l-arginine) forms the typical BH...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Krzyaniak, Matthew D., Cruce, Alex A., Vennam, Preethi, Lockart, Molly, Berka, Vladimir, Tsai, Ah-Lim, Bowman, Michael K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362310/
https://ncbi.nlm.nih.gov/pubmed/27989753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2016.10.503
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