Linear pharmacokinetics of 3,4-methylenedioxypyrovalerone (MDPV) and its metabolites in the rat: relationship to pharmacodynamic effects

3,4-Methylenedioxypyrovalerone (MDPV) is a commonly abused synthetic cathinone in the United States and is associated with dangerous side effects. MDPV is a dopamine transporter blocker that is 10-fold more potent than cocaine as a locomotor stimulant in rats. Previous in vitro and in vivo metabolis...

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Udgivet i:Addict Biol
Main Authors: Anizan, Sebastien, Concheiro, Marta, Lehner, Kurt R., Bukhari, Mohammad O., Suzuki, Masaki, Rice, Kenner C., Baumann, Michael H., Huestis, Marilyn A.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362107/
https://ncbi.nlm.nih.gov/pubmed/25475011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/adb.12201
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