Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams

Polycyclic tetramate macrolactams (PTMs) are a growing class of natural products and are derived from a hybrid polyketide synthase (PKS)/non-ribosomal peptide synthetase (NRPS) pathway. PTM biosynthetic gene clusters are conserved and widely distributed in bacteria, however, most of them remain sile...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Saha, Subhasish, Zhang, Wenjun, Zhang, Guangtao, Zhu, Yiguang, Chen, Yuchan, Liu, Wei, Yuan, Chengshan, Zhang, Qingbo, Zhang, Haibo, Zhang, Liping, Zhang, Weimin, Zhang, Changsheng
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361873/
https://ncbi.nlm.nih.gov/pubmed/28451290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc03875a
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