Pterostilbene prevents AKT-ERK axis-mediated polymerization of surface fibronectin on suspended lung cancer cells independently of apoptosis and suppresses metastasis

BACKGROUND: Polymeric fibronectin (polyFN) assembled on suspended breast cancer cells is required for metastasis. Conceivably, drugs that target such polyFN may fight against cancer metastasis. While stilbene analogs trigger pro-apoptotic effect on attached cancer cells, whether they prevent polyFN...

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Veröffentlicht in:J Hematol Oncol
Hauptverfasser: Wang, Ying-Jan, Lin, Jing-Fang, Cheng, Li-Hsin, Chang, Wen-Tsan, Kao, Ying-Hsien, Chang, Ming-Min, Wang, Bour-Jr, Cheng, Hung-Chi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361845/
https://ncbi.nlm.nih.gov/pubmed/28327179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-017-0441-z
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