Fibronectin and laminin promote differentiation of human mesenchymal stem cells into insulin producing cells through activating Akt and ERK

BACKGROUND: Islet transplantation provides a promising cure for Type 1 diabetes; however it is limited by a shortage of pancreas donors. Bone marrow-derived multipotent mesenchymal stem cells (MSCs) offer renewable cells for generating insulin-producing cells (IPCs). METHODS: We used a four-stage di...

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Bibliografiske detaljer
Main Authors: Lin, Hsiao-Yun, Tsai, Chih-Chien, Chen, Ling-Lan, Chiou, Shih-Hwa, Wang, Yng-Jiin, Hung, Shih-Chieh
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915967/
https://ncbi.nlm.nih.gov/pubmed/20624296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-17-56
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