DNA double-strand breaks in human induced pluripotent stem cell reprogramming and long-term in vitro culturing

BACKGROUND: Human induced pluripotent stem cells (hiPSCs) play roles in both disease modelling and regenerative medicine. It is critical that the genomic integrity of the cells remains intact and that the DNA repair systems are fully functional. In this article, we focused on the detection of DNA do...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Simara, Pavel, Tesarova, Lenka, Rehakova, Daniela, Matula, Pavel, Stejskal, Stanislav, Hampl, Ales, Koutna, Irena
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361733/
https://ncbi.nlm.nih.gov/pubmed/28327192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-017-0522-5
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