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The Aberrant DNA Methylation Profile of Human Induced Pluripotent Stem Cells Is Connected to the Reprogramming Process and Is Normalized During In Vitro Culture

The potential clinical applications of human induced pluripotent stem cells (hiPSCs) are limited by genetic and epigenetic variations among hiPSC lines and the question of their equivalency with human embryonic stem cells (hESCs). We used MethylScreen technology to determine the DNA methylation prof...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:PLoS One
Main Authors: Tesarova, Lenka, Simara, Pavel, Stejskal, Stanislav, Koutna, Irena
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919089/
https://ncbi.nlm.nih.gov/pubmed/27336948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0157974
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