Aspirin induces cell death by directly modulating mitochondrial voltage-dependent anion channel (VDAC)

Aspirin induces apoptotic cell death in various cancer cell lines. Here we showed that silencing of VDAC1 protected HeLa cells from aspirin-induced cell death. Compared to the wild type cells, VDAC1 knocked down cells showed lesser change of mitochondrial membrane potential (Δψ(m)), upon aspirin tre...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Tewari, Debanjan, Majumdar, Dhriti, Vallabhaneni, Sirisha, Bera, Amal Kanti
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361111/
https://ncbi.nlm.nih.gov/pubmed/28327594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45184
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