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Expression of IL-22 in the Skin Causes Th2-Biased Immunity, Epidermal Barrier Dysfunction and Pruritus via Stimulating Epithelial Th2 Cytokines and the GRP Pathway

Increased expression of Th22 cytokine IL-22 is a characteristic finding in atopic dermatitis (AD). However, the specific role of IL-22 in the pathogenesis of AD in vivo has yet to be elucidated. Consistent with observations in human AD, IL-22 was significantly increased in the AD skin of mice after...

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Dettagli Bibliografici
Pubblicato in:J Immunol
Autori principali: Lou, Hongfei, Lu, Jingning, Choi, Eun Byul, Oh, Min Hee, Jeong, Mingeum, Barmettler, Sara, Zhu, Zhou, Zheng, Tao
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360537/
https://ncbi.nlm.nih.gov/pubmed/28228560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600126
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