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YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis
Branching morphogenesis is a fundamental program for tissue patterning. We show that active YAP, a key mediator of Hippo signaling, is distributed throughout the murine lung epithelium and loss of epithelial YAP severely disrupts branching. Failure to branch is restricted to regions where YAP activi...
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| Veröffentlicht in: | eLife |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications, Ltd
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5360446/ https://ncbi.nlm.nih.gov/pubmed/28323616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21130 |
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