YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis

Branching morphogenesis is a fundamental program for tissue patterning. We show that active YAP, a key mediator of Hippo signaling, is distributed throughout the murine lung epithelium and loss of epithelial YAP severely disrupts branching. Failure to branch is restricted to regions where YAP activi...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Lin, Chuwen, Yao, Erica, Zhang, Kuan, Jiang, Xuan, Croll, Stacey, Thompson-Peer, Katherine, Chuang, Pao-Tien
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Developmental Biology and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360446/
https://ncbi.nlm.nih.gov/pubmed/28323616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21130
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