Ex vivo Akt inhibition promotes the generation of potent CD19CAR T cells for adoptive immunotherapy

BACKGROUND: Insufficient persistence and effector function of chimeric antigen receptor (CAR)-redirected T cells have been challenging issues for adoptive T cell therapy. Generating potent CAR T cells is of increasing importance in the field. Studies have demonstrated the importance of the Akt pathw...

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Bibliografiska uppgifter
I publikationen:J Immunother Cancer
Huvudupphovsmän: Urak, Ryan, Walter, Miriam, Lim, Laura, Wong, ChingLam W., Budde, Lihua E., Thomas, Sandra, Forman, Stephen J., Wang, Xiuli
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2017
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359873/
https://ncbi.nlm.nih.gov/pubmed/28331616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-017-0227-4
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