The cerebroventricular environment modifies CAR T cells for potent activity against both central nervous system and systemic lymphoma

Lymphomas with central nervous system (CNS) involvement confer a worse prognosis than those without CNS involvement, and patients currently have limited treatment options. T cells genetically engineered with CD19-targeted chimeric antigen receptors (CAR) are effective against B-cell malignancies and...

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Publicat a:Cancer Immunol Res
Autors principals: Wang, Xiuli, Huynh, Christian, Urak, Ryan, Weng, Lihong, Walter, Miriam, Lim, Laura, Vyas, Vibhuti, Chang, Wen-Chung, Aguilar, Brenda, Brito, Alfonso, Sarkissian, Aniee, Bandara, N. Achini, Yang, Lu, Wang, Jinhui, Wu, Xiwei, Zhang, Jianying, Priceman, Saul J., Qin, Hong, Kwak, Larry W., Budde, Lihua E., Thomas, Sandra H., Clark, Mary C., Popplewell, Leslie, Siddiqi, Tanya, Brown, Christine E., Forman, Stephen J.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8008993/
https://ncbi.nlm.nih.gov/pubmed/33093217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-20-0236
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