Application of an E. coli signal sequence as a versatile inclusion body tag

BACKGROUND: Heterologous protein production in Escherichia coli often suffers from bottlenecks such as proteolytic degradation, complex purification procedures and toxicity towards the expression host. Production of proteins in an insoluble form in inclusion bodies (IBs) can alleviate these problems...

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Bibliographic Details
Published in:Microb Cell Fact
Main Authors: Jong, Wouter S. P., Vikström, David, Houben, Diane, van den Berg van Saparoea, H. Bart, de Gier, Jan-Willem, Luirink, Joen
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359840/
https://ncbi.nlm.nih.gov/pubmed/28320377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-017-0662-4
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