12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT

TPA stimulates carcinogenesis in various types of cancers. However, we found that TPA inhibits transformative phenotypes in liver cancer cells via the translocation of YAP from the nucleus, where it functions as a transcriptional co-factor, to the cytoplasm. Such effects led to a separation of YAP f...

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Vydáno v:Sci Rep
Hlavní autoři: Zhu, Guoqing, Chen, Yan, Zhang, Xiao, Wu, Qi, Zhao, Yinghui, Chen, Yuxin, Sun, Fenyong, Qiao, Yongxia, Wang, Jiayi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359578/
https://ncbi.nlm.nih.gov/pubmed/28322318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44940
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