12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT

TPA stimulates carcinogenesis in various types of cancers. However, we found that TPA inhibits transformative phenotypes in liver cancer cells via the translocation of YAP from the nucleus, where it functions as a transcriptional co-factor, to the cytoplasm. Such effects led to a separation of YAP f...

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Pubblicato in:Sci Rep
Autori principali: Zhu, Guoqing, Chen, Yan, Zhang, Xiao, Wu, Qi, Zhao, Yinghui, Chen, Yuxin, Sun, Fenyong, Qiao, Yongxia, Wang, Jiayi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359578/
https://ncbi.nlm.nih.gov/pubmed/28322318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44940
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