Serelaxin Treatment Reduces Oxidative Stress and Increases Aldehyde Dehydrogenase-2 to Attenuate Nitrate Tolerance

Background: Glyceryl trinitrate (GTN) is a commonly prescribed treatment for acute heart failure patients. However, prolonged GTN treatment induces tolerance, largely due to increased oxidative stress and reduced aldehyde dehydrogenase-2 (ALDH-2) expression. Serelaxin has several vasoprotective prop...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Leo, Chen Huei, Fernando, Dhanushke T., Tran, Lillie, Ng, Hooi Hooi, Marshall, Sarah A., Parry, Laura J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359255/
https://ncbi.nlm.nih.gov/pubmed/28377719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00141
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