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Serelaxin treatment reverses vascular dysfunction and left ventricular hypertrophy in a mouse model of Type 1 diabetes

Serelaxin prevents endothelial dysfunction in the mouse aorta ex vivo and inhibits apoptosis in cardiomyocytes under acute hyperglycaemia. Less is known about the effects of serelaxin in an in vivo mouse model of diabetes. Therefore, we tested the hypothesis in streptozotocin (STZ)-treated mice that...

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Detalhes bibliográficos
Publicado no:Sci Rep
Principais autores: Ng, Hooi Hooi, Leo, Chen Huei, Prakoso, Darnel, Qin, Chengxue, Ritchie, Rebecca H., Parry, Laura J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5220363/
https://ncbi.nlm.nih.gov/pubmed/28067255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39604
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