Tb(3+)-Cleavage Assays Reveal Specific Mg(2+) Binding Sites Necessary to Pre-fold the btuB Riboswitch for AdoCbl Binding

Riboswitches are RNA elements that bind specific metabolites in order to regulate the gene expression involved in controlling the cellular concentration of the respective molecule or ion. Ligand recognition is mostly facilitated by Mg(2+) mediated pre-organization of the riboswitch to an active tert...

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Bibliographic Details
Published in:Front Chem
Main Authors: Choudhary, Pallavi K., Gallo, Sofia, Sigel, Roland K. O.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359240/
https://ncbi.nlm.nih.gov/pubmed/28377919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2017.00010
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