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Coupling of calcium and substrate binding through loop alignment in the outer membrane transporter BtuB
In Gram-negative bacteria, TonB-dependent outer membrane transporters (TBDTs) bind large, scarce organometallic substrates with high affinity preceding active transport. The cobalamin transporter BtuB requires the additional binding of two Ca(2+) ions before substrate binding can occur, but the unde...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2775145/ https://ncbi.nlm.nih.gov/pubmed/19747487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.09.004 |
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