Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression

We have generated mice with a floxed fak allele under the control of keratin-14-driven Cre fused to a modified estrogen receptor (CreER(T2)). 4-Hydroxy-tamoxifen treatment induced fak deletion in the epidermis, and suppressed chemically induced skin tumor formation. Loss of fak induced once benign t...

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Detalhes bibliográficos
Main Authors: McLean, Gordon W., Komiyama, Noboru H., Serrels, Bryan, Asano, Hidefumi, Reynolds, Louise, Conti, Francesco, Hodivala-Dilke, Kairbaan, Metzger, Daniel, Chambon, Pierre, Grant, Seth G.N., Frame, Margaret C.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC535910/
https://ncbi.nlm.nih.gov/pubmed/15601818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.316304
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