Pancreatic α- and β-cellular clocks have distinct molecular properties and impact on islet hormone secretion and gene expression

A critical role of circadian oscillators in orchestrating insulin secretion and islet gene transcription has been demonstrated recently. However, these studies focused on whole islets and did not explore the interplay between α-cell and β-cell clocks. We performed a parallel analysis of the molecula...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Petrenko, Volodymyr, Saini, Camille, Giovannoni, Laurianne, Gobet, Cedric, Sage, Daniel, Unser, Michael, Heddad Masson, Mounia, Gu, Guoqiang, Bosco, Domenico, Gachon, Frédéric, Philippe, Jacques, Dibner, Charna
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358758/
https://ncbi.nlm.nih.gov/pubmed/28275001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.290379.116
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