Transcription factor Wilms’ tumor 1 regulates developmental RNAs through 3′ UTR interaction

Wilms’ tumor 1 (WT1) is essential for the development and homeostasis of multiple mesodermal tissues. Despite evidence for post-transcriptional roles, no endogenous WT1 target RNAs exist. Using RNA immunoprecipitation and UV cross-linking, we show that WT1 binds preferentially to 3′ untranslated reg...

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Bibliographic Details
Published in:Genes Dev
Main Authors: Bharathavikru, Ruthrothaselvi, Dudnakova, Tatiana, Aitken, Stuart, Slight, Joan, Artibani, Mara, Hohenstein, Peter, Tollervey, David, Hastie, Nick
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2017
Subjects:
Research Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358755/
https://ncbi.nlm.nih.gov/pubmed/28289143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.291500.116
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