PP25. DISTRIBUTION OF IDH1 AND TERT MUTATIONS AND MGMT METHYLATION IN ADULT LOWER GRADE GLIOMA

IDH1 encodes for isocitrate dehydrogenase which catalyzes the oxidative carboxylation of isocitrate to α-ketoglutarate. Mutations in IDH1 are heterozygous and affect only codon 132. IDH1 mutation results in global hypermethylation (G-CIMP phenotype) and is significantly associated with MGMT promoter...

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Publié dans:Neuro Oncol
Auteurs principaux: Singh, Dr Anushree, Karakoula, Dr Katherine, Ashton, Mrs Kate, Dawson, Prof Tim, Davis, Prof Charles, Brodbelt, Mr Andrew, Jenkinson, Mr Michael, Darling, Prof John, Warr, Prof Tracy
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358587/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now293.024
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