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PP25. DISTRIBUTION OF IDH1 AND TERT MUTATIONS AND MGMT METHYLATION IN ADULT LOWER GRADE GLIOMA
IDH1 encodes for isocitrate dehydrogenase which catalyzes the oxidative carboxylation of isocitrate to α-ketoglutarate. Mutations in IDH1 are heterozygous and affect only codon 132. IDH1 mutation results in global hypermethylation (G-CIMP phenotype) and is significantly associated with MGMT promoter...
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| Опубликовано в: : | Neuro Oncol |
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| Главные авторы: | , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5358587/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now293.024 |
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