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Enantioselective allylic alkylation of stereodefined polysubstituted copper enolates as an entry to acyclic quaternary carbon stereocentres

A sequence of regio- and stereoselective carbometalation followed by oxidation of ynamides leads to stereodefined fully substituted enolates that subsequently react with various functionalized allyl bromide reagents to provide the expected products possessing an enantiomerically pure quaternary carb...

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Foilsithe in:Chem Sci
Main Authors: Nairoukh, Zackaria, Kumar, Gunda G. K. S. Narayana, Minko, Yury, Marek, Ilan
Formáid: Artigo
Teanga:Inglês
Foilsithe: Royal Society of Chemistry 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358538/
https://ncbi.nlm.nih.gov/pubmed/28451210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc03036j
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