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Reagent-controlled enantioselectivity switch for the asymmetric fluorination of β-ketocarbonyls by chiral primary amine catalysis

A reagent-controlled enantioselectivity switch was uncovered in the asymmetric α-fluorination of β-ketocarbonyls by a chiral primary amine catalyst. By a simple swap of fluorination reagents, both enantiomers of the quaternary fluorination adducts could be obtained with good yields and high enantios...

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Bibliografski detalji
Izdano u:Chem Sci
Glavni autori: You, Yang'en, Zhang, Long, Luo, Sanzhong
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358536/
https://ncbi.nlm.nih.gov/pubmed/28451209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc03109a
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