Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1

Apoptosis signal-regulating kinases (ASK1–3) are apical kinases of the p38 and JNK MAP kinase pathways. They are activated by diverse stress stimuli, including reactive oxygen species, cytokines, and osmotic stress; however, a molecular understanding of how ASK proteins are controlled remains obscur...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Weijman, Johannes F., Kumar, Abhishek, Jamieson, Sam A., King, Chontelle M., Caradoc-Davies, Tom T., Ledgerwood, Elizabeth C., Murphy, James M., Mace, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358389/
https://ncbi.nlm.nih.gov/pubmed/28242696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620813114
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