Adoptive immunotherapy of cancer with polyclonal, 10(8)-fold hyperexpanded, CD4(+ )and CD8(+ )T cells

T cell-mediated cancer immunotherapy is dose dependent and optimally requires participation of antigen-specific CD4(+ )and CD8(+ )T cells. Here, we isolated tumor-sensitized T cells and activated them in vitro using conditions that led to greater than 10(8)-fold numerical hyperexpansion of either th...

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Bibliografiske detaljer
Main Authors: Wang, Li-Xin, Huang, Wen-Xin, Graor, Hallie, Cohen, Peter A, Kim, Julian A, Shu, Suyu, Plautz, Gregory E
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2004
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC535812/
https://ncbi.nlm.nih.gov/pubmed/15566571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-2-41
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