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The role of hemoglobin heme loss in Heinz body formation: studies with a partially heme-deficient hemoglobin and with genetically unstable hemoglobins

A number of mutant hemoglobins are inordinately unstable, denaturing in circulating red cells into Heinz bodies, resulting in congenital Heinz body hemolytic anemia (CHBHA). We have emphasized that most such hemoglobins involve amino acid substitutions at sites neighboring the heme group of the β-po...

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Foilsithe in:J Clin Invest
Main Authors: Jacob, Harry S., Winterhalter, Kaspar H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 1970
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC535779/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/5475984/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI106421
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