Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway

Cellular senescence is an important in vivo mechanism that prevents the propagation of damaged cells. However, the precise mechanisms regulating senescence are not well characterized. Here, we find that ITGB3 (integrin beta 3 or β3) is regulated by the Polycomb protein CBX7. β3 expression accelerate...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Rapisarda, Valentina, Borghesan, Michela, Miguela, Veronica, Encheva, Vesela, Snijders, Ambrosius P., Lujambio, Amaia, O’Loghlen, Ana
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357738/
https://ncbi.nlm.nih.gov/pubmed/28273461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.02.012
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