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Mechanism of excessive purine biosynthesis in hypoxanthine-guanine phosphoribosyltransferase deficiency

Certain gouty subjects with excessive de novo purine synthesis are deficient in hypoxanthineguanine phosphoribosyltransferase (HG-PRTase [EC 2.4.2.8]). The mechanism of accelerated uric acid formation in these patients was explored by measuring the incorporation of glycine-(14)C into various urinary...

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Bibliografiska uppgifter
I publikationen:J Clin Invest
Huvudupphovsman: Sorensen, Leif B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 1970
Ämnen:
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC535769/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/5441549/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI106316
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