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Mechanism of excessive purine biosynthesis in hypoxanthine-guanine phosphoribosyltransferase deficiency

Certain gouty subjects with excessive de novo purine synthesis are deficient in hypoxanthineguanine phosphoribosyltransferase (HG-PRTase [EC 2.4.2.8]). The mechanism of accelerated uric acid formation in these patients was explored by measuring the incorporation of glycine-(14)C into various urinary...

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Autore principale: Sorensen, Leif B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1970
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC535769/
https://ncbi.nlm.nih.gov/pubmed/5441549
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