Vascular K(ATP) channels mitigate severe muscle O(2) delivery-utilization mismatch during contractions in chronic heart failure rats

The vascular ATP-sensitive K+ (K(ATP)) channel is a mediator of skeletal muscle microvascular oxygenation (PO(2)mv) during contractions in health. We tested the hypothesis that K(ATP) channel function is preserved in chronic heart failure (CHF) and therefore its inhibition would reduce PO(2)mv and e...

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Detalhes bibliográficos
Publicado no:Respir Physiol Neurobiol
Main Authors: Holdsworth, Clark T., Ferguson, Scott K., Colburn, Trenton D., Fees, Alexander J., Craig, Jesse C., Hirai, Daniel M., Poole, David C., Musch, Timothy I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357564/
https://ncbi.nlm.nih.gov/pubmed/28119150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.resp.2017.01.009
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