The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries

The docking protein p140Cap negatively regulates tumour cell features. Its relevance on breast cancer patient survival, as well as its ability to counteract relevant cancer signalling pathways, are not fully understood. Here we report that in patients with ERBB2-amplified breast cancer, a p140Cap-po...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Grasso, Silvia, Chapelle, Jennifer, Salemme, Vincenzo, Aramu, Simona, Russo, Isabella, Vitale, Nicoletta, Verdun di Cantogno, Ludovica, Dallaglio, Katiuscia, Castellano, Isabella, Amici, Augusto, Centonze, Giorgia, Sharma, Nanaocha, Lunardi, Serena, Cabodi, Sara, Cavallo, Federica, Lamolinara, Alessia, Stramucci, Lorenzo, Moiso, Enrico, Provero, Paolo, Albini, Adriana, Sapino, Anna, Staaf, Johan, Di Fiore, Pier Paolo, Bertalot, Giovanni, Pece, Salvatore, Tosoni, Daniela, Confalonieri, Stefano, Iezzi, Manuela, Di Stefano, Paola, Turco, Emilia, Defilippi, Paola
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357316/
https://ncbi.nlm.nih.gov/pubmed/28300085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14797
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