The Weighting Is The Hardest Part: On The Behavior of the Likelihood Ratio Test and the Score Test Under a Data-Driven Weighting Scheme in Sequenced Samples

Sequence-based association studies are at a critical inflexion point with the increasing availability of exome-sequencing data. A popular test of association is the sequence kernel association test (SKAT). Weights are embedded within SKAT to reflect the hypothesized contribution of the variants to t...

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Detalhes bibliográficos
Publicado no:Twin Res Hum Genet
Main Authors: Minică, Camelia C., Genovese, Giulio, Hultman, Christina M., Pool, René, Vink, Jacqueline M., Neale, Michael C., Dolan, Conor V., Neale, Benjamin M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357183/
https://ncbi.nlm.nih.gov/pubmed/28238293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/thg.2017.7
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