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The Weighting Is The Hardest Part: On The Behavior of the Likelihood Ratio Test and the Score Test Under a Data-Driven Weighting Scheme in Sequenced Samples
Sequence-based association studies are at a critical inflexion point with the increasing availability of exome-sequencing data. A popular test of association is the sequence kernel association test (SKAT). Weights are embedded within SKAT to reflect the hypothesized contribution of the variants to t...
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| Publicat a: | Twin Res Hum Genet |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5357183/ https://ncbi.nlm.nih.gov/pubmed/28238293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/thg.2017.7 |
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