Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts

BACKGROUND: Polo-like kinase 4 PLK4 plays a key role in centriole replication. Hence PLK4 inhibition disrupts mitosis, and offers a novel approach to treating chromosomally unstable cancers, including pancreatic cancer. CFI-400945 is a first in class small molecule PLK4 inhibitor, currently undergoi...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Lohse, Ines, Mason, Jacqueline, Mary, Pinjiang Cao, Pintilie, Melania, Bray, Mark, Hedley, David W
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2016
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356865/
https://ncbi.nlm.nih.gov/pubmed/27902970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13619
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