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Substrate requirements for let-7 function in the developing zebrafish embryo

MicroRNAs (miRNAs) are involved in the regulation of gene expression at the post-transcriptional level by base pairing to the 3′-UTR (untranslated region) of mRNAs. The let-7 miRNA was first discovered in Caenorhabditis elegans and is evolutionarily conserved. We used zebrafish embryos as a vertebra...

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Main Authors: Kloosterman, Wigard P., Wienholds, Erno, Ketting, René F., Plasterk, Ronald H.A.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2004
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC535676/
https://ncbi.nlm.nih.gov/pubmed/15585662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh968
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