Heregulin-expressing HER2-positive breast and gastric cancer exhibited heterogeneous susceptibility to the anti-HER2 agents lapatinib, trastuzumab and T-DM1

BACKGROUND: Overexpression of heregulin, a HER3 ligand, is one mechanism that confers resistance to the anti-HER2 agents trastuzumab and lapatinib. We investigated the impact of heregulin expression on the efficacy of HER2-targeted therapeutic agents, including trastuzumab, trastuzumab emtansine (T-...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Nonagase, Yoshikane, Yonesaka, Kimio, Kawakami, Hisato, Watanabe, Satomi, Haratani, Koji, Takahama, Takayuki, Takegawa, Naoki, Ueda, Hiroto, Tanizaki, Junko, Hayashi, Hidetoshi, Yoshida, Takeshi, Takeda, Masayuki, Chiba, Yasutaka, Tamura, Takao, Nakagawa, Kazuhiko, Tsurutani, Junji
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356704/
https://ncbi.nlm.nih.gov/pubmed/27768588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12743
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