Combined Analysis of Plasma Amphiregulin and Heregulin Predicts Response to Cetuximab in Metastatic Colorectal Cancer

BACKGROUND: Amphiregulin, a ligand of the epidermal growth factor receptor (EGFR), is associated with the efficacy of cetuximab, an antibody against EGFR, as treatment for colorectal cancer (CRC). In contrast, the HER3 ligand heregulin correlates with cetuximab resistance. In this study, we evaluate...

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Pubblicato in:PLoS One
Autori principali: Yonesaka, Kimio, Takegawa, Naoki, Satoh, Taroh, Ueda, Hiroto, Yoshida, Takeshi, Takeda, Masayuki, Shimizu, Toshio, Chiba, Yasutaka, Okamoto, Isamu, Nishio, Kazuto, Tamura, Takao, Nakagawa, Kazuhiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646631/
https://ncbi.nlm.nih.gov/pubmed/26569500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143132
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