Combined Analysis of Plasma Amphiregulin and Heregulin Predicts Response to Cetuximab in Metastatic Colorectal Cancer

BACKGROUND: Amphiregulin, a ligand of the epidermal growth factor receptor (EGFR), is associated with the efficacy of cetuximab, an antibody against EGFR, as treatment for colorectal cancer (CRC). In contrast, the HER3 ligand heregulin correlates with cetuximab resistance. In this study, we evaluate...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Yonesaka, Kimio, Takegawa, Naoki, Satoh, Taroh, Ueda, Hiroto, Yoshida, Takeshi, Takeda, Masayuki, Shimizu, Toshio, Chiba, Yasutaka, Okamoto, Isamu, Nishio, Kazuto, Tamura, Takao, Nakagawa, Kazuhiko
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646631/
https://ncbi.nlm.nih.gov/pubmed/26569500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143132
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