Combined Analysis of Plasma Amphiregulin and Heregulin Predicts Response to Cetuximab in Metastatic Colorectal Cancer

BACKGROUND: Amphiregulin, a ligand of the epidermal growth factor receptor (EGFR), is associated with the efficacy of cetuximab, an antibody against EGFR, as treatment for colorectal cancer (CRC). In contrast, the HER3 ligand heregulin correlates with cetuximab resistance. In this study, we evaluate...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Yonesaka, Kimio, Takegawa, Naoki, Satoh, Taroh, Ueda, Hiroto, Yoshida, Takeshi, Takeda, Masayuki, Shimizu, Toshio, Chiba, Yasutaka, Okamoto, Isamu, Nishio, Kazuto, Tamura, Takao, Nakagawa, Kazuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646631/
https://ncbi.nlm.nih.gov/pubmed/26569500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143132
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