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Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome.

Anti-Ku (p70/p80) autoantibodies in patients with scleroderma-polymyositis overlap syndrome recognize a 70-kDa/80-kDa protein heterodimer which binds to terminal regions of double-stranded DNA. In the present study, we isolated full-length cDNAs that encode the 80-kDa Ku subunit. Initial screening o...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphov: Mimori, T, Ohosone, Y, Hama, N, Suwa, A, Akizuki, M, Homma, M, Griffith, A J, Hardin, J A
Materialtyp: Artigo
Språk:Inglês
Utgiven: National Academy of Sciences 1990
Ämnen:
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53566/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2308937/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.5.1777
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