The identification of a novel role for BRCA1 in regulating RNA polymerase I transcription

The unrestrained proliferation of cancer cells requires a high level of ribosome biogenesis. The first stage of ribosome biogenesis is the transcription of the large ribosomal RNAs (rRNAs); the structural and functional components of the ribosome. Transcription of rRNA is carried out by RNA polymera...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Johnston, Rebecca, D'Costa, Zenobia, Ray, Swagat, Gorski, Julia, Harkin, D. Paul, Mullan, Paul, Panov, Konstantin I.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356541/
https://ncbi.nlm.nih.gov/pubmed/27589844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11770
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