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Fluorinative ring-opening of cyclopropanes by hypervalent iodine reagents. An efficient method for 1,3-oxyfluorination and 1,3-difluorination

A new method is presented for 1,3-difluorination and 1,3-oxyfluorination reactions. The process is based on iodonium mediated opening of 1,1-disubstituted cyclopropanes. The reaction proceeds with high chemo- and regioselectivity under mild reaction conditions typically at room temperature in a coup...

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Bibliografiske detaljer
Udgivet i:Chem Sci
Main Authors: Ilchenko, Nadia O., Hedberg, Martin, Szabó, Kálmán J.
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356504/
https://ncbi.nlm.nih.gov/pubmed/28451244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc03471c
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