Matrix metalloproteinase activity stimulates N-cadherin shedding and the soluble N-cadherin ectodomain promotes classical microglial activation

BACKGROUND: Matrix metalloproteinases (MMPs) are a family of enzymes that are typically released from intracellular stores to act on specific extracellular substrates. MMP expression and activity can be increased in a neuronal activity-dependent manner, and further increased in response to tissue in...

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Bibliographische Detailangaben
Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Conant, Katherine, Daniele, Stefano, Bozzelli, P. Lorenzo, Abdi, Tsion, Edwards, Amanda, Szklarczyk, Arek, Olchefske, India, Ottenheimer, David, Maguire-Zeiss, Kathleen
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356362/
https://ncbi.nlm.nih.gov/pubmed/28302163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0827-4
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