Comprehensive analysis of The Cancer Genome Atlas reveals a unique gene and non-coding RNA signature of fibrolamellar carcinoma

Fibrolamellar carcinoma (FLC) is a unique liver cancer primarily affecting young adults and characterized by a fusion event between DNAJB1 and PRKACA. By analyzing RNA-sequencing data from The Cancer Genome Atlas (TCGA) for >9,100 tumors across ~30 cancer types, we show that the DNAJB1-PRKACA fus...

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Udgivet i:Sci Rep
Main Authors: Dinh, Timothy A., Vitucci, Eva C. M., Wauthier, Eliane, Graham, Rondell P., Pitman, Wendy A., Oikawa, Tsunekazu, Chen, Mengjie, Silva, Grace O., Greene, Kevin G., Torbenson, Michael S., Reid, Lola M., Sethupathy, Praveen
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356346/
https://ncbi.nlm.nih.gov/pubmed/28304380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44653
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