Veliparib in combination with radiotherapy for the treatment of MGMT unmethylated glioblastoma

BACKGROUND: The O (6)-methylguanine methyltransferase (MGMT) gene is frequently unmethylated in patients with glioblastoma (GBM), rendering them non-responsive to the standard treatment regime of surgery followed by concurrent radiotherapy (RT) and temozolomide. Here, we investigate the efficacy of...

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Veröffentlicht in:J Transl Med
Hauptverfasser: Jue, Toni Rose, Nozue, Kyoko, Lester, Ashleigh J., Joshi, Swapna, Schroder, Lisette B. W., Whittaker, Shane P., Nixdorf, Sheri, Rapkins, Robert W., Khasraw, Mustafa, McDonald, Kerrie L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356284/
https://ncbi.nlm.nih.gov/pubmed/28314386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1164-1
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