Efficient Precision Genome Editing in iPSCs via Genetic Co-targeting with Selection

Genome editing in induced pluripotent stem cells is currently hampered by the laborious and expensive nature of identifying homology-directed repair (HDR)-modified cells. We present an approach where isolation of cells bearing a selectable, HDR-mediated editing event at one locus enriches for HDR-me...

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Bibliografiske detaljer
Udgivet i:Stem Cell Reports
Main Authors: Mitzelfelt, Katie A., McDermott-Roe, Chris, Grzybowski, Michael N., Marquez, Maribel, Kuo, Chieh-Ti, Riedel, Michael, Lai, Shuping, Choi, Melinda J., Kolander, Kurt D., Helbling, Daniel, Dimmock, David P., Battle, Michele A., Jou, Chuanchau J., Tristani-Firouzi, Martin, Verbsky, James W., Benjamin, Ivor J., Geurts, Aron M.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355643/
https://ncbi.nlm.nih.gov/pubmed/28238794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.01.021
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